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Disturbances in GSH homeostasis have been implicated in neurodegenerative disorders, liver disease, cystic fibrosis, pulmonary and cardiovascular diseases, as well as the chronic age-related diseases and the aging process itself.Recent data also suggests it plays a role in metabolic and inflammatory diseases such as multiple sclerosis, the metabolic syndrome, and diabetes, at least in part by influencing the effect of multiple environmental toxins, an underappreciated yet surprisingly significant association
Reduced CII activity has consequences for central carbon metabolism because CII is involved in the conversion of succinate to fumarate within the TCA cycle 73
It is integral to collagen structure-approximately one-third of the amino-acid content of collagen (the main connective-tissue protein) is glycine
As complex, multifactorial diseases influenced by genetic and environmental factors, they typically have a slow onset, with patients often testing positive for autoantibodies years before showing any clinical signs or symptoms (79)
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