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Participants received once-weekly injections of retatrutide at either the 9mg or 12mg dose, or a placebo, over 68 weeks
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Potent GLP-1 agonists exert effects by multiple mechanisms including delayed gastric emptying, increased glucose-dependent insulin secretion, reduced glucagon levels, and reduced food intake by CNS effects to cause appetite suppression
A human-derived tendon cell model 6 demonstrated increased collagen expression and improved matrix structure following IGF-1 exposure, showing potential benefits for joint and tendon recovery
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