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Tirzepatide (Mounjaro for diabetes and Zepbound for obesity, both Eli Lilly), a dual GLP-1/GIP agonist titrated gradually across a broad dosing range, showed a favorable safety profile, with GIP agonism probably buffering GLP-1-mediated fluid shifts, stabilizing vascular tone and reducing ischemic vulnerability
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They mimic a natural hormone that controls hunger and blood sugar
Medicare has gone in the opposite direction and began covering obesity GLP-1s for Medicare beneficiaries as of July 1
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