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Patients regularly report decreased hunger, improved energy levels, and reductions in cravings during semaglutide treatment
Mechanistically, 4-HBGs neuroprotective efficacy against glutamate excitotoxicity has been attributed to competitive inhibition of kainate receptor binding ( 3.6 Brain tissue distribution of GEB extract in normal and MCAO rats Cerebral distribution analysis revealed distinct patterns of six GEB-derived compounds (PA, PB, PC, PE, GAS, 4-HBG) between normal and MCAO rats following oral administration (Figure 8)
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