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What to Expect Every milestone below is an animal result or an uncontrolled user report

Individuals with certain health conditions, such as Lebers disease (a rare inherited eye disease), should avoid B12 supplements as it can worsen the condition

According to the NIH Office of Dietary Supplements, functional B12 deficiency is most commonly seen in patients with one or more of the following: Age over 50 stomach acid production declines with age, and stomach acid is required to free B12 from food PPI or H2 blocker use reflux medications suppress the acid needed for B12 absorption Metformin use, which interferes with B12 absorption directly Vegan or vegetarian diets B12 is found almost exclusively in animal products Gut conditions including celiac, IBS, SIBO, and Crohns MTHFR mutations that affect how B12 is metabolized once absorbed Heavy alcohol use The symptoms of low B12 are easy to dismiss: fatigue, brain fog, low mood, tingling in the hands or feet, weakness, and shortness of breath on mild exertion

Low Starting Amount Amount per injection: 2.5 mg 50 units (0.50 mL) on a U-100 insulin syringe Frequency: Once daily, under the skin (subcutaneous) Cycle length: One 5 mg vial = 2 days at the starting amount Sources: [1] Selective small-molecule inhibitors of NNMT reverse high-fat-diet-induced obesity in mice PubMed