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10.1016/s0016-5085(12)60808-7 50 SchijnsW.HomanJ.van der MeerL.JanssenI

AOD 9604 has a substantial history of clinical study

5-Amino-1MQ instead removes a drain on that route: by inhibiting NNMT it prevents nicotinamide from being methylated to 1-methylnicotinamide, leaving it available for NAMPT and the salvage pathway, and simultaneously spares the S-adenosyl-L-methionine that the methylation would have consumed