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However, uncertainties persist regarding the prospects for adverse liver effects that might be inherent to the mechanism of action, as stabilisation of hepatic steatosis would be unwelcome
265,266 When GLP-1 binds to its receptors in the hypothalamus, it activates specific neurons, including those that promote satiety (POMC/CART neurons) and inhibits those that induce hunger (NPY/AgRP neurons), thereby enhancing the feeling of fullness and reducing food intake
The anorectic effects of GLP-1 agonism are reported to result from the suppression of AgRP/NPY neurons and activation of POMC/CART neurons, and these responses occur upstream of MC4R [28, 29]
Even medications with lower reported rates still cause this side effect in a subset of patients
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