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Moreover, emerging evidence has shown that the SGLT2i and GLP-1RA combination therapy was associated with fewer cardiovascular events in the population with T2DM and MI, compared to either drug used alone [98]
Furthermore, in 3-month-old transgenic 5xFAD mice, liraglutide reduced astrocyte activation and A deposition while increasing levels of insulin-degrading enzyme (IDE) [52]
Your genetic variants in GLP-1 receptor sensitivity (GLP1R rs6923761) and glucose-dependent insulinotropic peptide receptors (GIPR rs1800437) influence how efficiently your cells respond to the medication and how quickly your body processes it
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