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In rare cases, more serious side effects can develop
According to a study published in PubMed Central (National Institutes of Health), intravenous administration of vitamin B12 provides a faster increase in B12 levels compared to oral supplementation, making it a potentially better option for patients with severe deficiency
Copper itself is a comparatively weak skin sensitizer a 2014 review (PMID 25098945) reported positive copper patch-test reactions in roughly 3.8% of tested subjects so contact allergy is possible but uncommon
The most commonly reported side effects at therapeutic doses include mild nausea, particularly in the first week of a protocol, which typically resolves by day 7 to 10 without any dose adjustment
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