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The researchers now want to investigate whether this drug also has the potential to treat humans with type 2 diabetes and whether the efficacy of this new combination therapy can be optimized further using biochemical modifications
Healthy microbiota produces short-chain fatty acids (SCFAs) like butyrate for anti-inflammatory effects
We combined our drug with a "carrier molecule" called SNAC, provided by our partner Emisphere
Additionally, matrix metalloproteinase inhibitors are administered in the later acute phase to broadly suppress MMP-9 activity, mitigating degradation of the basement membrane and tight junction proteins (207)
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