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Patients should be counseled ahead of time that transient worsening of diabetic retinopathy or macular edema can happen whenever there is rapid glucose improvement, but that there are significant long-term benefits for diabetic retinopathy
Most patients begin to notice weight loss during the first month
Medicare excluded them for nearly two decades even as the same drugs got covered for other uses, like diabetes or heart disease
Homocysteine would also contribute to the LDL oxidative modifications mediated by endothelial cells, macrophages, and smooth muscle cells (Heinecke et al, 1987
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