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Chronic stress, environmental toxins, diets low in nutrients but high in inflammatory triggers, sleep deprivation, smoking, sugar, excess alcohol, and other stressors slowly deplete glutathione levels

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Their passive first line of defense includes physical barriers such as trichomes, cuticles, and wax, that averts pathogens and insects, followed by their capability of producing chemical compounds that defends themselves from pathogen infections (Zaynab et al., 2018)