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G6PD-Deficiency and PPP in B cells While limited in generalizability to B cells, one study of antibody production in industrial fed-batch hamster ovarian carcinoma cells demonstrated peak flux through the PPP during the late exponential phase of IgG production and sustained PPP activity through the stationary and decline phases

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Taking these supplements can lead to dangerous side effects and create thyroid issues in people with healthy thyroid function ( One study that analyzed 10 thyroid supplements found that the majority of them contained detectable amounts of T3 and T4

But heres the catch: a large 2026 systematic review of the NAD+ research looking at over a hundred human and animal studies found zero controlled trials proving IV or injectable NAD+ actually improves anti-aging or wellness outcomes in otherwise healthy people