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For example, there has only been one randomized controlled trial published on the effects that GLP-1s have on humans with SUD (Free et al., 2024)

In the STEP 1 trial, published in the New England Journal of Medicine (2021), which enrolled over 1,900 adults with obesity or overweight, a substantial proportion of participants were taking lipid-lowering medicines at baseline

However, small increases are not always dangerous