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The initiation dose of 0.25 mg already requires 25 units, which consumes a quarter of the syringe

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(2017) Endogenous glucagon-like peptide-1 receptor signaling in the nucleus tractus solitarius is required for food intake control

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in such situations, reduction in the doses of these medicines should be considered

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Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs) reduce incidence of cardiovascular events in type 2 diabetes (T2D) patients

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