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weight loss at target dose (trial data) ~15% (STEP 1) CV risk reduction labelled Yes (SELECT obesity + CVD) Format Prefilled pen India price (May 2026) 5,66016,400/month (Poviztra co-marketed: 3,9998,999/month) DCGI-approved Yes (20252026) Generic competition in India n/a (innovator) Generic semaglutide 9+ Indian manufacturers Active molecule Semaglutide Receptor activity GLP-1 Primary indication T2D &/or obesity (brand-dependent) Max maintenance dose 0.52.4 mg weekly Avg
Ethical considerations also play a role
I got the prior authorization you required for me, and now youre mid-year taking it away from me is so impactful that it should be illegal. Although coverage exceptions may be an option, the appeals process takes time
Conformational instability Short duration of action and are rapidly cleared by the liver and kidneys Hard to penetrate into the tissue you need it (particularly the blood brain barrier for uses to help the brain nervous system) They breakdown in the stomach, so hard to give the peptide orally
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