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Supplementary material The Supplementary Material for this article can be found online at: References 1 AmatullahH.Maron-GutierrezT.ShanY.GuptaS.TsoporisJ
Patients should contact a healthcare provider for severe or persistent abdominal pain, pain radiating to the back, persistent vomiting, dehydration, symptoms of gallbladder disease, signs of low blood sugar when used with insulin or insulin secretagogues, or symptoms of an allergic reaction
The lack of participant blinding in the other 2 studies meant that they were open label RCTs
There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH
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