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The pharmacology is different enough that CagriSema results cannot be assumed to transfer to a tirzepatide pairing

AOD9604 and Cartilage Biology Research In a collagenase-induced knee osteoarthritis rabbit model, intra-articular injection of AOD9604 significantly enhanced cartilage regeneration compared to saline controls, with combined AOD9604 and hyaluronic acid injections proving more effective than either treatment alone producing superior morphological and histopathological scores and a significantly shorter lameness period in the AOD9604 + HA group

In animal models, GLP-1RAs inhibited myocardial fibrosis and reduced ventricular hypertrophy

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