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[25] [26] The ADA and KDIGO recommend SGLT2 inhibitors for patients with type 2 diabetes and CKD (eGFR 20), atherosclerotic cardiovascular disease, or heart failure

A study of postmenopausal women with overweight or obesity, published in the Lancet Obstetrics, Gynaecology, & Womens Health in early 2026, found that women taking tirzepatide plus hormone replacement therapy lost more weight than women taking tirzepatide alone

Drug safety update: GLP-1 receptor agonists: reports of diabetic ketoacidosis when concomitant insulin was rapidly reduced or discontinued

There are several challenges and uncertainties in this process (52), and key scientific challenges encountered in the use of chronic disease endpoints to establish nutrient requirement values have been reviewed (53)