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Key steps in GLP-1 signaling, as shown in Figure 1, include: The ligand GLP-1 binds to the GLP-1R, a G-coupled protein receptor
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Therefore, NGRA focus on determining whether a substance triggers in vitro bioactivity at human-relevant concentrations and, consequently, adverse health effects, in lieu of replicating apical endpoints that would traditionally be obtained using high-dose animal studies (Baltazar et al., 2020
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