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Key trial programs include SURMOUNT (tirzepatide for weight management, NEJM 2022), SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024), and STEP (semaglutide, NEJM 2021)
Functional capacity typically expands progressively during this period
Moreover, the combination of glucagon with GLP-1 actions could improve WL while protecting against the risk of hyperglycaemia [64]
Understanding the two is important, as each one has different considerations regarding compound exposure, handling, study design, and overall research goals
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