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If you can lower that peak without significantly changing the total weekly drug exposure, you might reduce the intensity of side effects while preserving the therapeutic benefit

Kristensen SL, Rrth R, Jhund PS, Docherty KF, Sattar N, Preiss D, Kber L, Petrie MC, McMurray JJV (2019) Cardiovascular, mortality, kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials

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Capozzi ME, Wait JB, Koech J et al (2019) Glucagon lowers glycemia when cells are active