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Furthermore, M1 macrophage-derived exosomes reduce E-cadherin expression in the intestinal barrier by secreting miR-21a-5p, which exacerbates intestinal inflammation in UC model mice and destroys the structure and function of the intestinal barrier
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p=0.026), as well as on mean changes in the KCCQ-CCS scores (6.9 difference versus placebo
When testing each drug type separately, we estimate the effect of the SNP on BMI % to be larger in tirzepatide (effect = 0.95%) than semaglutide (effect = 0.51%), although the 95% confidence intervals were overlapping (Extended Data Fig
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