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Research published through the National Center for Biotechnology Information details how coordinated activation of GLP-1 and GIP receptors modulates glucose-dependent intracellular signaling, while simultaneous glucagon receptor engagement alters cellular lipid oxidation pathways

According to the Summary of Product Characteristics (SmPC) approved by the Medicines and Healthcare products Regulatory Agency (MHRA), gastrointestinal disturbances occur in a significant proportion of patients, with nausea affecting up to 20% of users

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Risk of stomach ulcer is rare, and PPI therapy is to be continued until removal