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instead, a more recent study revealed that melatonin-mediated mPTP inhibition would be highly dependent on the MT1 receptor as mitochondrial protective effects did not occur in the presence of luzindole compound, an MT blocking agent 56
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To surpass this ceiling, tumor-selective strategies are urgently neededinterventions that increase the therapeutic index by concentrating cytotoxic effects on malignant tissue while sparing normal structures
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