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Although not yet completed, cardiovascular outcomes of tirzepatide will likely be similar to GLP-1 RAs based on the mechanism of the drug
They work through several mechanisms that are relevant even when your pancreas no longer makes insulin: they slow gastric emptying (meaning food hits your bloodstream more gradually), suppress glucagon release (the hormone that raises blood sugar), and reduce appetite
Pancreapedia: Exocrine Pancreas Knowledge Base
By changing these signals, semaglutide helps people feel less hungry and reduces the desire to eat large portions of food
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