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Ferroptosis inducers, such as RSL3, lead to the removal of O-GlcNAc from serine 179 of the ferritin heavy chain, which increases its binding to the ferritin receptor NCOA4

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Contraindications and clinical precautions include: Medullary thyroid carcinoma (MTC): Cagrilintide is contraindicated in individuals with a personal or family history of MTC due to its structural similarity to calcitonin, which may theoretically influence C-cell activity