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Cell 85 : 149158 Buschmann T, Potapova O, Bar-Shira A, Ivanov VN, Fuchs SY, Henderson S, Fried VA, Minamoto T, Alarcon-Vargas D, Pincus MR, Gaarde WA, Holbrook NJ, Shiloh Y and Ronai Z (2001) Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
A negligible fraction of cells were propidium iodide + alone, indicating that X(PC) does not merely initiate unprogrammed necrotic cell death in SUP-B15 cells but rather directly activates a pyroptotic lytic death through caspase activation
Hence, elucidation of the underlying mechanisms for cell premature senility may be a key to our understanding of liver fibrosis pathogenesis
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