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The hybrid nanoparticles target tumors effectively, overcoming common drug resistance mechanisms by inhibiting the PI3K/AKT/mTOR pathway, generating ROS, and depleting glutathione (GSH), leading to enhanced cancer cell apoptosis

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Chlorogenic acid stabilizes cell function by eliminating mitochondrial damage, increases PINK1-dependent mitosis, inhibits apoptosis of liver cells, and prevents APAP hepatotoxicity (Hu et al., 2022)