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Elevated homocysteine has been linked with brain atrophy, cognitive decline, and an increased risk of dementia, making it one of the most widely studied biomarkers of brain health
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Phase III trials were carried out as part of the SURPASS programme to investigate its therapeutic effectiveness (glycaemic control and body weight reduction) and safety/tolerability for the treatment of patients with type 2 diabetes [90, 91]
Using this model, we performed two supplementary experiments: (i) ex vivo islet exposure to excessive zinc (Supplementary information, Fig
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