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For semaglutide users who want a no-frills, evidence-based probiotic that targets diarrhea and immune support, Culturelle is hard to beat on a value basis

Understanding why requires appreciating how weight loss itself affects thyroid function: Weight loss reduces leptin levels , which can decrease TRH (thyrotropin-releasing hormone) secretion from the hypothalamus, potentially lowering TSH Improved insulin sensitivity may alter thyroid hormone metabolism and conversion of T4 to T3 Reduced inflammation from fat loss can change the thyroid hormonal milieu Changes in body composition affect thyroid hormone distribution and binding A retrospective study of over 21,000 patients found that hypothyroid individuals using semaglutide experienced modest TSH decreases alongside weight loss

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Calibration plots confirmed the model was well calibrated in the test set (Extended Data Fig