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A metastasis-prone signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics

Structural and pharmacological studies demonstrate that Cagrilintide binds these receptor complexes with high affinity in a manner that resembles endogenous amylin while incorporating modifications that increase peptide stability and prolong receptor engagement [2]

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A compound may have promising animal data, plausible biology or significant consumer interest long before there are large human trials