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This longevity of research interest is itself informative: compounds that fail to replicate across independent laboratories typically disappear from the literature within a decade
Administration is typically brief, and patients generally return to normal activity immediately
This "retinization" period is a recognized feature of retinoid therapy, not a sign of a bad product
And so if the demands are not decreasing, but our body's ability to produce glutathione is decreasing, then there's a gap on what your demand versus what your supply is
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