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Amgen's MariTide, Pfizer's danuglipron, and several other candidates are advancing through clinical trials

Leading up to the Metsera acquisition, Pfizer management was pretty open about its interest in doing a deal to re-enter this space with differentiated long-acting and oral GLP-1 candidates

Briefly, at typical physiological GSH concentrations and pH, the reaction between ONOO - and GSH will predominantly be a two electron oxidation process leading to GSSG formation (Quijano et al., 1997)

This difference is not just academicit's fundamental to understanding potential side effects, including the very topic we're discussing today