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However, in ex vivo cardiomyocyte models, TMAO concentrations (100 M10 mM) did not significantly alter oxidative stress markers nor enhance the cytotoxicity of known oxidative stress inducers, suggesting it may not serve as a direct mediator of acute cardiac oxidative stress (Querio et al., 2019)

The most effective foods to help increase GLP-1 naturally include legumes (lentils and black beans), whole grains like oats and barley, and healthy fats like avocado and extra virgin olive oil

To mechanistically link these metabolic alterations with gene expression dynamics, we constructed a trans-omic network model integrating differentially expressed genes (pink nodes) and metabolites (blue squares) through known biochemical associations and literature-curated interactions (Fig

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