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Relative Contraindications: Injection into Fingers & Toes Historically, the injection of epinephrine containing solutions into end-artery structures such as fingers and toes has been widely discouraged due to the concern that prolonged vasoconstriction may cause vascular insufficiency resulting in tissue necrosis and permanent injury

For this purpose, the findings obtained in the rats with infrarenal occlusion of the inferior caval vein may be noteworthy (Vukojevic et al., 2018)

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Upper arm injections should only be administered by a caregiver, not self-administered