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The risk of these tumors may depend on the dosage given and how long the treatment lasts Additionally, tirzepatide is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)
161 Unlike other pharmacodynamic effects, such as lowering blood glucose or reducing appetite, the delay in gastric emptying shows tachyphylaxis, with the effect gradually decreasing over time
The fat metabolism theory suggests GIPs effects on adipose tissue are crucial
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