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This guide covers every step of that process, from the pharmacology of why tapering matters to the exact dose reduction schedule, the lifestyle changes that actually work, and the warning signs that mean you should slow down or reconsider

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Both compounds have half-lives suitable for once-weekly dosing: Tirzepatide: ~5-day half-life Retatrutide: ~6-day half-life (estimated from Phase 2 pharmacokinetic data) Best Peptides for Fat Loss: Where Do These Compounds Rank