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As shown in Figure 5A, as the concentration of methylglyoxal increased, PC12 cell viability gradually decreased, and the cell viability dropped to approximately 50% at the methylglyoxal dose of 2.0 mM
Uezumi A, Fukada S, Yamamoto N, Ikemoto-Uezumi M, Nakatani M, Morita M, et al
It serves a mechanical purpose
According to a 2022 review, gastrointestinal side effects, including constipation, were among the most commonly reported adverse effects of GLP-1 receptor agonists, especially during the dose-escalation phase in about 25-35% of users
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