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Ethics declarations Acknowledgements This work was undertaken as part of UK Biobank project application ref 56653 Pharmacogenomics to improve drug efficacy and safety

It is worth noting that unlicensed medicines can be lawfully supplied in limited circumstances for example, as 'specials' manufactured to meet the specific clinical needs of an individual patient under a prescriber's direction

For patients suffering from the painful tingling, numbness, and burning sensations of peripheral neuropathy, B12 supplementation may offer a physiological pathway to relief and holds promise for supporting the autonomic and peripheral nervous systems in complex post-viral syndromes