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For body composition optimization, metabolic syndrome, insulin resistance, and patients seeking measurable changes in energy and fat distribution
For B12, prolonged use of metformin and acid-suppressing drugs (PPIs, H2 blockers) may reduce absorption of oral B12, which is one reason injectable B12 is considered in select patients
Blood levels of P1NP (procollagen type I N-terminal propeptide), a marker of bone formation, also increased significantly, while markers of bone degradation decreased
It does not appear toxic, does not accumulate in tissues, and has been well tolerated in trials
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