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Examination of the GCL from these different organisms suggests that the interplay between the redox-sensitive thiol-switch and dimerization of the plant enzymes occurred later in evolution and may be related to compartmentalization of glutathione synthesis in the chloroplast (Gromes et al., The sub-organellar localization of GCL raises questions about redox regulation of glutathione biosynthesis in plants
doi:10.1039/c1pp05232b
Brain Res 25:6479
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