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This randomised, double-blind, placebo-controlled trial enrolled 706 adults with overweight or obesity (BMI 27 or above) across multiple dose groups, running over 26 weeks
& Vinggaard, A
first reported a polymorphism in GPx1, namely, a substitution at codon 198 of either proline (Pro) or leucine (Leu), Pro198Leu (SNP: 1050450), in lung cancer [87]
Findings suggest that it may initiate signaling cascades involving PI3K and AMPK, pathways associated with nutrient regulation and energy use
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