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10.1073/PNAS.0505723102 164 ScarffeL
Chronic sleep deprivation (less than 7 hours nightly) disrupts appetite-regulating hormones, increases ghrelin, decreases leptin, and promotes insulin resistanceall of which may counteract tirzepatide's mechanisms
L., Thgersen, H., Madsen, K., Ankersen, M., & Andersen, P
Lane 3 remains the most effective, yet cost, access, and side effects are real constraints, and multi-year safety for broad weight-management use is still being studied
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