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Effects on weight are small and inconsistent
Soliqua 100/33 (active ingredients: insulin glargine and lixisenatide) subcutaneous injection Initial FDA Approval: 2016 Side Effect Update Date: May 28, 2025 Medication Description: Treats type 2 diabetes Updated Side Effects/Safety Information: A new warning section on Severe Gastrointestinal Adverse Reactions. An additional new warning about the risk of serious kidney injury caused by dehydration due to gastrointestinal adverse effects like diarrhea and vomiting
The liver is the primary site of P450 enzyme activity, and there are over 50 different P450 enzymes with unique substrate specificity
Bowel Obstruction: Studies show a link between Trulicity and an increased risk of bowel obstruction, particularly for those new to the medication (had been taking the drug for less than one month)
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