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Treatment begins with a low dose that is gradually increased over several weeks to minimise gastrointestinal side effects and allow the body to adjust to the medication
This was further substantiated by the observation that inhibiting heightened GJ function with a GJ inhibitor in mice effectively diminished APAP toxicity, which correlated with reduced levels of oxidative stress in hepatocytes
2 The absorption rate decreased by 53%, meaning paracetamol reached peak blood levels more slowly
Even with careful dosing adjustments, some people cant tolerate these effects and choose to stop the medication
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