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Youll work with your provider on a structured, physician-supervised transition off medication
Never increase your dose faster than your prescribing provider recommends
The molecular events leading to activation or silencing of glucose-sensitive neurons are surprisingly similar to those of the endocrine pancreas and include neuronal uptake of glucose via GLUT2, conversion to pyruvate (and finally ATP) via glucokinase, and modulation of neuronal firing mediated by changes in K ATP channel activity, cell depolarisation and Ca 2+ influx
Given that retatrutide is being studied partly for its glucose-lowering properties, maintaining stable blood sugar through dietary choices is an important complementary strategy
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