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The mean duration of type 2 diabetes mellitus was 8.6 years, and the mean BMI was 32 kg/m2
Similarly, once the inducing agent is removed, the effects on hepatocytes may take a few weeks to resolve (time for the xenobiotic to be cleared and for enzymes to degrade)
The absolute difference in liver fat content [LFC] was 4.7% (95% CI from 6.7 to 2.7), with a relative decrease in LFC from baseline of 35.9% and 28.4% for the two individual dosages ( p 40%, renal death, new onset of macroalbuminuria) strongly favored tirzepatide (HR 0.58, 95% CI from 0.43 to 0.80, p = 0.0008)
Oral administration Oral peptides face significant bioavailability challenges
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