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12% of initial body weight at 28 weeks
However, this is only one example, which isn't adequate to prove the safety of GLP-1 agonists in pregnancy
Risk increases with: Too few calories or skipped meals , leading to protein breakdown for energy Inadequate protein intake , especially near minimal dietary requirements rather than weight-lossappropriate targets Lack of resistance training , removing the signal to maintain muscle Micronutrient deficiencies , such as low vitamin D, which can impair muscle function Preventing undernutrition dramatically reduces the risk of clinically meaningful muscle loss. How Common Is Lean-Mass Loss with GLP-1/GIP Therapy
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