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2.3.3.2 The GSH/Grx system The GSH/Grx system plays key roles in controlling signaling and imbalance in thiol-disulfide redox homeostasis and redox reactions, which are linked to the development and progression of oxidative stress-related disorders (Chai and Mieyal, 2023), and the GSH-Grx system consists of NADPH, glutathione reductase, GSH and Grx (Lu and Holmgren, 2014)